Physical Characteristic of the Aorta in Young Stroke-Prone Hypertensive Rat

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Even in younger age, the aortic walls of SHRSP, especially in males, were shown to be brittle or fragile in comparison with those of WK. In spite of their thickening, they showed poor extension. In order to clarify whether or not this fragility is due to the qualitative or quantitative difference in vascular components, and to clarify whether such difference is detected in small cerebral arteries where hypertensive vascular lesions are induced, further study is necessary. Even if such difference is noted only in the aorta, the absorbing function of greater pulse pressure may be less in the aortas of SHRSP because of reduction in elasticity. Such an impairment of aortic function may be involved in the stroke-proneness of SHRSP, where cerebral vessels might be possibly exposed to greater pulsatile changes in blood pressure.
International Heart Journal刊行会の論文