Physico-Morphological Characteristics of Aorta in Stroke-Prone and -Resistant Spontaneously Hypertensive Rats

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The aorta of SHR was thickened with hyperplasia and hypertrophy of medial cells and with the increase of elastic component after the development of hypertension. The aorta of stroke-prone SHR, in spite of the similar thickening to that of stroke-resistant SHR, was obviously less elastic than the latter. The stress-elongation diagrams which showed that the former aorta succumbed into a ductile failure to lesser stress than the latter were suggestive of the brittleness of the vasculature in stroke-prone SHR, although it was not yet determined whether the fragility was due to the primary or secondary defects.(The authors acknowledge the advice and instruction of Prof. J. Takamura and Dr. N. Narita, Faculty of Technology, Kyoto University. This study was supported by Science and Technology Agency of Japanese Government, the Ministry of Education and Japan Society for the Promotion of Science.)
International Heart Journal刊行会の論文