ラット灌流筋におけるグルコース利用とインスリン分解に及ぼすグルコースおよびインスリン濃度の影響

概要

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It is well known that the muscle is a main target organ of insulin, where insulin stimulates glucose transport into skeletal muscle1-4) and is degraded by skeletal mus-cle7-11). It has been reported that in rat hepatocytes5) and adipocytes6), the glucose dose modulates the effect of insulin on glucose uptake, but the role of glucose in modulating the effect of insulin in muscle is not known. Also, the analysis of insulinmetabolism, in vitro, has been extensively performed with investigating the purification and the characterization of insulin degrading enzyme8, 10, 11). However, up to now, the insulin metabolism of the perfused muscle has not been examined in detail.In the present experiments, therefore, the effects of physiological concentrations of insulin and different concentrations of glucose on glucose uptake of the perfused muscle of rat hindquarter has been studied, and simultaneous measurements made of insulin degradation rate by muscle under the physiological condition.
社団法人日本畜産学会の論文