A study on size of molecular aggregates formed by bile acid in human gallbladder bile : With special reference to comparison of bile with chenodeoxycholic acid treatment and bile with ursodeoxycholic acid treatment.:With Special Reference to Comparison of

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The size of molecular aggregates (generally, micelle) formed by bile acid in human gallbladder bile was studied by utilizing disposal ultrafiltration unit (cut-off molecular weight: 10, 000 and 1, 000).In gallbladder bile without any bile acid treatment (n=20), 66% of total bile acid was observed in large aggregate fraction (molecular weight: above 10, 000) and 18% in small particle fraction (dimer and monomer). In bile with chenodeoxycholic acid treatment (n=8) the large fraction was increased to 73% of total bile acid and small fraction was decreased to 13%, as compared with gallbladder bile without any bile acid treatment. On the otherhand, in bile with ursodeoxycholic acid treatment (n=8), large fraction was decreased to 59% and small fraction was increased to 24%. Additionally, it should be noted that major constituent of dimer and monomer was cholic acid or ursodeoxycholic acid. Thus, distribution of size of molecular aggregates in bile with chenodeoxycholic aicd treatment was significantly different from that in bile with ursodeoxycholic acid treatment.
財団法人日本消化器病学会の論文