Inhibitory Effects of Alcohols on the Activity of Human Matrix Metalloproteinase 7 (Matrilysin)
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概要
- 論文の詳細を見る
Aliphatic alcohols inhibited the activity of human matrix metalloproteinase 7 (matrilysin) competitively with Ki of 6.1–19.4% (v/v) or 0.66–4.80 M. From the relationship between the structures of alcohols and their Ki values, alcohols are considered to bind the hydrophobic S1′ subsite most plausibly, and the size of the pocket was estimated to be large enough to accommodate the length of 1-butanol (4-carbon chain) and the bulk of tertiary alcohols. Alcohols might be suitable probes for exploring the active-site geometry of enzymes.
- 社団法人 日本農芸化学会の論文
- 2004-12-23
著者
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Inouye K
Kyoto Univ. Kyoto Jpn
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Inoue K
Kansai Medical Univ. Osaka
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INOUYE Kuniyo
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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ONEDA Hiroshi
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Oneda H
Kyoto Univ. Kyoto Jpn
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Oneda Hiroshi
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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Muta Y
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Muta Yuko
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Inouye K
Kyoto Univ. Kyoto
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Inouye Kuniyo
Division If Applied Life Sciences Graduate School Of Agriculture Kyoto University
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