ゲンノショウコの有効成分の研究(第1報) : 腸管収縮活性物質

概要

論文の詳細を見る
Effective principles of Geranii Herba were investigated by Magnus' method. G-A, having a strong contractile activity on isolated intestines of guinea pig, was prepared from the basic fraction of aqueous extract of Geranii Herba. The contractile activity of G-A was about a thousand times as effective as that of the aqueous extract per se (G-l). Thus, the contractile activity of G-l might be ascribable to G-A. Paper partition chromatography and the like method showed that G-A consisted of choline and a trace of acetylcholine-like substance. The diarrheal activity of G-A, choline chloride and acetylcholine chloride was examined on mice. The diarrheal activity of G-A was almost equal to that of choline chloride and about one tenth of that of acetyl-choline chloride.
日本生薬学会の論文
1980-06-20