オオバギボウシ(Hosta sieboldiana)由来F-gitoninの好中球様細胞刺激能

概要

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86 plant and mushroom extracts were screened for stimulated effects on nitroblue tetrazolium (NBT) reducing activities of retinoic acid-induced (RA-induced) HL60 cells. As a result, NBT-formazan deposits were detected in over 10 % of the cells by the treatment of extracts from Allium grayi, Angelica ursina, Aralia cordata, A. elata, Cacalia hastana var. glabra, Condrus ocellatus, Desmarestia viridis, Dictyota dichotoma, D. lastiuscula, Ecklonia stolonifera, Gelidium amansii, Glehnia littoralis, Hemerocallis fulva, Hosta albo-marginata, H. sieboldina, Lomentaria catenata, Lentinus edodes, Pilea hamaoi, Pleurotus ostreatus, Sambucus sieboldiana, Sargassum honeri, S. thunbergii, Undaria pinnatifida and Zingiber mioga. The methanol extracts of H. sieboldiana provoked marked stimulative effects on NBT reducing activities of RA-induced HL60 cells, and we isolated active compound I from the extract. Physical data were identical with those of F-gitonin, a spirostane-type of steroidal saponin. We showed stimulative effects of F-gitonin on the O_2 release from RA-induced HL60 cells.
日本生薬学会の論文
2002-08-20