80.新規オーキシン極性輸送阻害剤の合成と活性(口頭発表)

概要

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Auxin regulates diverse developmental processes. Many of these processes such as apical dominance, gravitropism, and phototropism are depend on regulated auxin transport. Therefore, the regulation of auxin transport plays a crucial role in plant development. The auxin polar movement is achieved by auxin influx and efflux transport proteins localized in plant cell membrane. Auxin efflux carrier proteins, PIN play central role in the regulation of auxin movement. This auxin movement is inhibited by synthetic auxin transport inhibitors, such as NPA. Auxin transport inhibitors have been widely used for the investigation of the physiological role and molecular action of auxin transport. However, exact nature of this inhibitionby NPA is unknown. We here demonstrate the new polar auxin transport (PAT) inhibitors with novel mode of action. New PAT inhibitor is auxin analogues and would block the auxin efflux movement by directly inhibiting auxin efflux carrier proteins. In our model, our new PAT inhibitors binds to auxin recognition site of PINs, auxin channel, and blocks the movement of auxin through auxin channel of PIN.
植物化学調節学会の論文
2008-10-06