55 クスノキ科Neolitsea aciculata Koidz.の高度酸化セスキテルペノイドの構造(ポスター発表の部)

概要

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In our continuing studies on Lauraseae, which are widely distributed in Japan, we have isolated three germacrane-type sesquiterpenes, named neoliacinolide A(3), B(4), and C(5), and two elemane-type sesquiterpenes, sericealactonecarboxylic acid (7) and aciculatalactone (8), respectively, from the fresh leaves of Neolitsea aciculata Koidz. Structures of neoliacinolide A(3), B(4), and C(5) were determined mainly on the basis of 2D NMR (^1H-^1H, ^<13>C-^1H COSY, and COLOC) detailed spectral analysis as shown in the text as well as by comparison of the spectral data with those of neoliacine (1) and neoliacinic acid (2). The relative stereochemistry of these compounds have been assigned from results of 2D NOESY. Additional new sesquiterpenoid aciculatalactone (8) having elemane-type skeleton was isolated along with sericealactonecarboxylic acid (7) which was the hydrated form of sericealactone (6), and its structure was established by using a variety of 2D NMR techniques and confirmed by single X-ray crystallographic method.
天然有機化合物討論会の論文
1992-09-10