微生物由来のオーキシン信号伝達阻害剤、B59-Aの作用機序

概要

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Bio-probes that modulate the action of auxin are useful tools for the study on auxin signaling. We have previously reported specific inhibitor, B59-A, on auxin signaling from Streptomyces sp.. B59-A inhibited auxin inducible gene expression such as AUX/IAA and SUAR-ACl gene from etiolated arabidopsis seedling. On the other hand, auxin inducible par A gene from tobacco protoplasts was induced by B59-A. However, the induction of ABA inducible Rab 18 gene was not affected. The auxin-specific, epinastic growth of tobacco leaf tissue was also blocked by B59-A. Aurovertin B (atpase inhibitor) and 9-anthracene carboxylic acid (9-AC, anion channel blocker) exhibited same biological activities as shown in B5-A. In addition, CCCP, uncoupler of membrane potential, inhibited auxin inducible gene expression. These results suggest that membrane potential and ion transport system are thought to play an essential role for the induction of auxin inducible gene.
植物化学調節学会の論文
2000-11-02