86 糸状菌の生産する痙攣作用物質(ポスター発表の部)

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During the course of searching for insecticidal compounds produced by strains of Penicilium simplicissimum, we found that the fermentation products of strains MF-24 and AK-40 exhibited convulsion against silkworms upon oral administration. We isolated and identified verruculogen (1) from a strain MF-24 as an active factor. Two convulsants, 2 and 3, were also isolated from the fungus P. simplicissimum AK-40 (ATCC 90288). 2 was identified as penitrem A. On the other hand, 3 was determined to be 6-bromopeniterm E, a new compound. Using this convenient bioassay with silkworm, we screened soil fungi for convulsive compounds. As a result we got an isolate of Penicillium sp. MG-11. Activity-based fractionation of the acetone extract of the fermentation products resulted in the isolation of four compounds. One was identified as verruculogen (1). Another compound, acetoxydehydroaustin (7), was new and was structurally characterized by spectral data and single crystal X-ray analysis. Two other compounds were identified as dehydroaustin (5) and austin (6) on the basis of the spectral data. The latter three compounds while not active themselves enhanced the convulsive activity of verruculogen in a silkworm bioassay. Three additional compounds with no identifiabel activity were also isolated. Two of them were identified as austinol (9) and dehydroaustinol (8), and the third one was determined to be a new related compound named neoaustin (10) by an X-ray analysis of crystals.
天然有機化合物討論会の論文
1993-09-10

86 糸状菌の生産する痙攣作用物質(ポスター発表の部)

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