4 放線菌の生産するテルペン化合物の生合成研究(口頭発表の部)

概要

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Several Streptomyces species were reported to biosynthesize terpenoidal compounds via the mevalonate pathway, while the biosynthesis of pentalenolactone, a common metabolite of Streptomyces, was explained by involvement of the non-mevalonate pathway disclosed recently. These findings suggest that the genus Streptomyces utilizes either one (or both) of two different pathways for the formation of isopentenyl diphosphate (IPP) depending on species. To address this unusual issue in more detail, we have studied the biosynthesis of a primary metabolite, ubiquinone, and a secondary metabolite, naphterpin produced by Streptomyces aeriouvifer. Labeling experiments using [6-^2H_2]glucose and [U-C_6]glucose showed that most of the ubiquinone molecules was produced by the non-mevalonate pathway. On the other hand, naphterpin which was produced at later stage of the fermentation was mainly produced by the classical mevalonate pathway. In addition, we have studied the biosynthesis of an unusual tetraterpenoid, longestin (KS-505) which is produced by Streptomyces argenteolus. It turned out that the producing organism possessed only the non-mevalonate pathway which was used for the formation of longestin.
1996-09-02