63 Viridenomycinの構造研究(ポスター発表の部)

概要

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During the course of our screening program for new antitumor antibiotics, we isolated an antibiotic, designated AL081, from the culture broth of an actinomycete identified as Streptomyces gannmycicus. Recently, AL081 was found to be identical with viridenomycin, an antifungal antibiotic, by direct comparison. The structure of viridenomycin, however, has not been clarified because of its instability in various solvents. The molecular formula of viridenomycin was established as C_<34>H_<37>NO_6 by FD-MS (m/z 556, MH^+) and elemental analysis (C 73.58, H6.56, N 2.42, O 17.44; calcd. C 73.49, H 6.71, N 2.52, O 17.28). The structure of viridenomycin was elucidated by using a variety of two-dimensional NMR techniques as shown in Fig. 1. The structure of viridenomycin is a novel 24-membered macrocyclic polyene lactam antibiotic. Viridenomycin prolonged the survival periods of mice bearing P388 leukemia (ILS 23.0%) and B16 melanoma cells (ILS 37.0%).
天然有機化合物討論会の論文
1991-09-07