51 ヤマブシタケ(Hericium erinaceum)の産生する神経成長因子(NGF)合成促進物質(口頭発表の部)

概要

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Nerve growth factor (NGF) is a protein required for development and maintenance of the neurons in the peripheral and the central nervous systems. Some recent studies suggest that the possible use of NGF as a therapeutic tool for degenerative neuronal disorders such as Alzheimer's disease and peripheral nerve regeneration. However, inability of NGF to pass through the blood-brain barrier limited its application. Stimulators of NGF-synthesis by brain cells, which can pass the barrier, have possibility to become the drugs for the disease. During screening for the stimulators, compounds 1 to 5 were isolated from the cultured mycelia of Hericium erinaceum. The structures of these compounds were determined by spectral data and chemical analyses. The compounds are novel diterpenes having same skeletons. All the compounds exhibited potent stimulating activity. In vivo-experiments about the compounds are now in progress.
1993-09-10