Synthesis and Biological Activities of 2,3-Dimethyl-1,4-benzoquinones Having Alkylthio and Arylthio Side Chains(Medicinal Chemistry,Chemical)
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概要
- 論文の詳細を見る
New 2,3-dimethyl-1,4-benzoquinones having an alkylthio or arylthio side chain at the 5-position and two alkylthio side chains at the 5- and 6-position were synthesized as possible antimetabolites of coenzyme Q. These compounds were tested for inhibition of coenzyrne Q in mitochondrial succinoxidase and reduced nicotinamide adenine dinucleotide (NADH)-pxidase systems, and were found to show greater inhibition of the NADH-oxidase system than of the succinoxidase system. 5,6-Di-octylthio-2,3-dimethyl-1,4-benzoquinone showed greater inhibitory activities than 5-alkylthio-2,3-dimethyl-1,4-benzoquinones. 5-Arylthio-2,3-dimethyl-1,4-benzoquinones showed potent inhibitory activities towards both enzyme systems.
- 社団法人日本薬学会の論文
- 1987-03-25
著者
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紀氏 健雄
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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高橋 京子
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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紀氏 健雄
神戸学院大学 薬学部
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森 浩一
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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佐用 博照
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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森 浩一
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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佐用 博照
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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