Kinetic Studies on the Decomposition of the 4-Diethylaminoantipyrine Cation Radical in Aqueous Acetonitrile Solutions
スポンサーリンク
概要
- 論文の詳細を見る
4-Diethylaminoantipyrine cation radical (II) was generated by the anodic oxidation of 4-diethylaminoantipyrine (I) in acetonitrile containing 0.1M NaClO_4 at a glassy-carbon anode, and the rate of disappearance of II in aqueous acetonitrile solutions was measured by spectrophotometry. In aqueous acetonitrile solutions of pH 7.4 and 10.4,II decayed in a first-order manner, and the first-order rate constant obtained increased with increasing concentration of the buffers and hydroxyl ions and with decreasing concentration of NaClO_4 added. On the other hand, in a solution containing 0.1M HClO_4,II decayed in a second-order manner. The second-order rate constant obtained was independent of the ionic strength of the solution and decreased with increasing concentration of acetonitrile. A mechanism for the decomposition of II is suggested.
- 公益社団法人日本薬学会の論文
- 1979-08-25
著者
-
佐用 博照
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
-
佐用 博照
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
関連論文
- Synthesis and Biological Activities of 2,3-Dimethyl-1,4-benzoquinones Having Alkylthio and Arylthio Side Chains(Medicinal Chemistry,Chemical)
- Electron Spin Resonance of Free Radicals Electrochemically Generated from Polynitroalkanes
- 定電位電解法の研究(第3報)ω-ニトロスチレンの定電位電解法
- 定電位電解法の研究(第2報)α, β-不飽和ニトロ化合物のポーラログラフィーによる研究
- ESR Study of Membrane Perturbation and the Lysis of Liposomes Induced by Chlorpromazine
- Electrochemical Oxidation of N-Nitrosopiperidines : Dual Pathways for N-Nitramine Formation
- Inhibition of Succinoxidase and Reduced Nicotinamide Adenine Dinucleotide (NADH) Oxidase by 2,3-Ethylenedioxy-1,4-benzoquinones Having Alkylthio and Arylthio Side Chains
- Studies on the Ethylhydroperoxide-Supported Oxidation of 1,4-Diazabicyclo[2.2.2]octane by Chloroperoxidase
- Cumene Hydroperoxide-Supported N-Demethylation of N, N-Dimethylanilines Catalyzed by Catalase
- Results of Spin Immunoassay for Simultaneous Measurement of Phenytoin and Phenobarbital in Serum Compared with Those of Liquid Chromatography
- Determination of Phenobarbital in Human Serum by Spin Immunoassay
- Electron Spin Resonance Studies on the Reaction of Peroxyphenylacetic Acid with Aminopyrine in the Presence and Absence of Catalase
- SIMULTANEOUS DETERMINATION OF PHENYTOIN AND PHENOBARBITAL IN SERUM BY SPIN IMMUNOASSAY
- The Utility of the Deuterated Spin Label in the Spin Immunoassay of Cortisol
- スピンイムノアッセイによる尿中遊離型コルチゾールの定量
- Kinetics of the Organic Hydroperoxide-supported Oxidation of Aminopyrine catalyzed by Catalase
- The Effect of Alkaline Denaturation on Organic Hydroperoxide-supported N-Demethylase Activities of Catalase
- Mechanism of N-Demethylation of Aminopyrine by Catalase-Organic Hydroperoxide Systems
- Electron Spin Resonance Studies on the Cumene Hydroperoxide-Supported Oxidation of Aminopyrine by Catalase
- Free Radical Intermediate in the N-Demethylation of Aminopyrine by Catalase-Cumene Hydroperoxide System
- スピンイムノアッセイによる尿中テストステロンの定量
- Inhibition of Mitochondrial Respiratory Chain by Arylthiolated 2,3-Ethylenedioxy-1,4-benzoquinones
- Electron Spin Resonance Spectra of N-Nitrosodialkylamine Radical Cations Electrochemically Generated in Solution
- Oxidation of Sulfides with Electrocatalytic P-450 Model System
- Studies on Sulfenamides. XIV. A New Method of Generating of 2,4-Dinitrobenzenesulfenylnitrene
- Biomimetic Oxidation of Diphenyl Sulfide with Metalloporphyrin-O_2-NaBH_4 System
- Synthesis and Characterization of "Picnic-Basket" Porphyrins with a Substituent in the Interior of the Pocket
- Studies on Sulfenamides. XIII. Reaction of 2-Nitrobenzene-sulfenanilides with N-Bromosuccinimide
- Anodic Oxidation of o-Nitrophenylthioiminocycloalkanes
- Studies on Sulfenamides. XII. : Anodic Oxidation of N-(o-Nitrophenylthio)-1,2,3,4-tetrahydroquinoline and N-(o-Nitrophenylthio)-1,2,3,4-tetrahydroisoquinoline
- Studies on Sulfenamides. XI. : Electron Spin Resonance Spectra of Radical Cations Electrochemically Generated from N, N-Disubstituted 2-Nitrobenzenesulfenamides
- Studies on Sulfenamides. X. Electron Spin Resonance Spectra of Radical Cations Electrochemically Generated from N-(o-Nitrophenylthio) alicyclic Amines
- Studies on Sulfenamides. IX. Anodic Oxidation of N-(o-Nitrophenylthio) alicyclic Amines
- Studies on Sulfenamides. VIII. Anodic Oxidation of 2-Nitrobenzenesulfenamides Derived from Secondary Cyclic Amines
- Studies on Sulfenamides. VII. Anodic Oxidation of 3'-and 2'-Substituted 2-Nitrobenzenesulfenanilides
- Studies on Sulfenamides. VI. Cyclic Voltammetry and Controlled Potential Electrolysis of 4'-Substituted 2-Nitrobenzenesulfenanilides in the Presence of Trifluoroacetic Acid or Pyridine
- Studies on Sulfenanilides. V. Anodic Oxidation of 4'-Substituted 2-Nitrobenzenesulfenanilides at a Reticulated Vitreous Carbon Electrode
- Studies on Sulfenamides. IV. Oxidation of 4'-, 3'-, and 2'-Substituted 2-Nitrobenzenesulfenanilides with Lead Dioxide
- Studies on Sulfenamides. III. Cyclic Voltammetry and Controlled Potential Electrolysis of 4'-Substituted 2-Nitrobenzenesulfenanilides
- Studies on Sulfenamides. II. Oxidation of 2-and 4'-Substituted Benzenesulfenanilides with Lead Dioxide
- Studies on Sulfenamides. I. Cyclic Voltammetry and Controlled Potential Electrolysis of 4'-Substituted Bezenesulfenanilides
- Oxidation of 4'-Substituted Benzenesulfenanilides with Lead Dioxide. Electron Spin Resonance Studies of Benzenesulfenanilidyl Radicals
- Anodic Oxidation of 2-and 4'-Substituted Benzenesulfenanilides. A New Method of Synthesis of 2,7-Disubstituted Phenazines
- Oxidation of N-Alkylhydroxylamines. IV. Anodic Oxidation of N-Alkylhydroxylamines
- Anodic Oxidation of Amines. IV. Cyclic Voltammetry and Controlled Potential Electrolysis of 4-Diethylaminoantipyrine in Acetonitrile
- Chloroperoxidase-Catalyzed Oxidation of Aminopyrine
- Cyclic Voltammetry and Controlled Potential Electrolysis of Benzenesulfon-p-anisidide
- C-C Bond Fission in Carboxamide. Intermediacy of Phenylcarbamate Ion in the Alkaline Hydrolysis of Trichloroacetanilide
- Anodic Oxidation of Sulfonamides. II. Anodic Oxidation of 4'-Substituted Benzenesulfonanilides in Acetonitrile
- Kinetic Studies on the Formation of Dimethylnitrosamine
- Oxidation of N-Alkylhydroxylamines. III. Reaction of N-Alkylhydroxylamines with 1,1-Diphenyl-2-picrylhydrazyl
- Controlled Potential Electrolysis. X. Polarographic Behavior and Electrolytic Reduction Process of Esters of Aliphatic α-Nitrocarboxylic Acids
- Oxidation of N-Alkylhydroxylamines. V. Anodic Oxidation of N, O-Dialkyl- and N, N, O-Trialkylhydroxylamines
- Oxidation of N-Alkylhydroxylamines. II. Reaction of N-Alkylhydroxylamines with tert-Butylhydroperoxide
- Oxidation of N-Alkylhydroxylamines. I. Nitroxides formed on Oxidation of N-Alkylhydroxylamines with Lead Tetraacetate
- Kinetic Studies on the Decomposition of the 4-Diethylaminoantipyrine Cation Radical in Aqueous Acetonitrile Solutions