Studies on the Ethylhydroperoxide-Supported Oxidation of 1,4-Diazabicyclo[2.2.2]octane by Chloroperoxidase
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概要
- 論文の詳細を見る
The chloroperoxidase-catalyzed oxidation of 1,4-diazabicyclo[2.2.2]octane (DABCO) by H_2O_2 or ethylhydroperoxide (EHP) in the presence of Cl^- was investigated at pH 2.75,5.0,and 7.0,and the results were compared with those of the chemical oxidation by HOCl. The oxidation of DABCO in the chloroperoxidase-EHP-Cl^- system at pH 5.0 gave a fairly well-resolved electron spin resonance spectrum, which was identified as that of the radical cation of DABCO. The detection of the radical cation suggests that the first step of the chloroperoxidase-catalyzed oxidation of DABCO is the formation of the DABCO chloroammonium cation followed by the homolysis of the cation.
- 公益社団法人日本薬学会の論文
- 1988-07-25
著者
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細川 幹夫
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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佐用 博照
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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仮家 公夫
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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細川 幹夫
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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李 英培
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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仮家 公夫
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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佐用 博照
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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