Mechanism of Potentiation of the Carcinostatic Activity of 8-Aza-guanine by 4 (or 5)-Aminoimidazole-5 (or 4)-carboxamide Analogs
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概要
- 論文の詳細を見る
The antitumor activity of 8-AG was potentiated by its administration with AICA or Aza-AICA to Ehrlich ascites carcinoma in mice. AICA or Aza-AICA alone had no carcinostatic actions, but Monomethyl-TICA alone was found to be slightly carcinostatic at the concentration used in these experiments. AICA and Monomethyl-TICA inhibited liver 8-AG deaminase activity of normal mice, but Aza-AICA did not. Neither AICA nor Aza-AICA affected the activity of the liver xanthine oxidase of normal mice. Therefore, the potentiating actions of AICA and Monomethyl-TICA on 8-AG may be to their inhibitory effects on 8-AG deaminase activity. That of Aza-AICA could be due to a different action from those of the former two compounds.
- 公益社団法人日本薬学会の論文
- 1969-03-25
著者
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西尾 英明
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University:(present Address)depa
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仮家 公夫
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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山本 格
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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羽野 寿
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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仮家 公夫
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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山本 格
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
-
羽野 寿
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University:(present Address)depa
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