PHARMACOLOGICAL STUDIES ON 4 (OR 5)-AMINOIMIDAZOLE-5 (OR 4)-CARBOXAMIDE (AICA) DERIVATIVES
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概要
- 論文の詳細を見る
In previous works from our laboratory (1-3) we reported that 4-diazoimidazole-5-carboxamide (diazo-ICA) and 4-(mono- or di-substituted) triazenoimidazole-5-carboxamide (mono- or dialkyl-TICA) showed marked inhibitory effects on the growth of tumors and bacterial cells. During examination of their toxicity in mice, behavioral sedation caused by these compounds was also observed (2). These observations led us to investigate the pharmacological properties of these compounds. The present report is on the effects of these compounds on the respiration, blood pressure, peripheral blood vessel and isolated intestine of the rabbit and the electroencephalogram (EEG) and electrocardiogram (EEG) of cats.
著者
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山本 格
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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羽野 寿
大阪大学薬学部
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岩田 平太郎
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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羽野 寿
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University:(present Address)depa
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明石 章
Central Research Laboratory, Daiich Seiyaku Co., Ltd.
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鈴木 幸子
Department of Pharmacology, Showa College of Pharmacy
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成実 重彦
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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岩田 平太郎
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka Universit
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羽野 寿
Department of Pharmacology, Osaka College of Pharmacy
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山本 格
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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