20602 ナノインデンテーションによるオステオンの弾性率分布計測と骨のマイクロリモデリング(OS9 バイオエンジニアリング)

概要

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A nano-indentation was performed for the cross section of a bovine femur. The inner lamella and outer lamella of four bone structural units, so called osteons, were tested at a rate of 1N/m. Modulus was obtained from the measurement with a depth of 1000nm. Results revealed that the modulus of lamella was higher in the outer lamella than in the inner lamella for immature osteons while the reverse was true for mature osteons. Meanwhile, a FEM analysis was performed for a micro bone model representing an osteon surrounded by interstitial bone. A bone remodeling algorithm was applied to the analysis in which the modulus of the bone model changed in response to compressive stress. Obtained results were coincident with the above-described experimental results. These results suggest that the bone remodeling due to mechanical stress occurs not only in macro level structures but also in micro level structures such as the osteon of cortical bone.
社団法人日本機械学会の論文
2005-03-17