547 3次元scaffold-free組織(3DST)を用いて再生されたブタ大腿顆部軟骨の力学特性(S09-3 関節のバイオメカニズム(3),S09 関節のバイオメカニズム)

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概要

Synovial cells obtained from the synovial membrane of porcine knee joints were cultured in DMEM for seven days after to develop 3-D scaffold-free synthetic tissues (3DSTs). A round shaped cartilage defect of 8mm in diameter and 1.5mm in depth was created on the medial condyle of the femur. The defect was filled with the 3DST, and the porcine were allowed cage activity. Six months after the surgery, a cylindrically shaped cartilage-subchondral bone specimen of 4mm in diameter and 5-8mm in depth was extracted and subjected to a dynamic test and a quasi-static compression test. At a rate of 100μm/s, the tangent modulus of the regenerated cartilage with 3DST was significantly higher than those of normal cartilage and regenerated cartilage without 3DST. However, the significant difference was disappeared at a rate of 4μm/s. Dynamic compression deformation of the regenerated cartilage with 3DST was same level as that of regenerated cartilage without 3DST, but was higher than those of normal cartilage. It was suggested that the 3DST provided the regenerated cartilage with viscoelastic properties.

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