548 3次元scaffold-free組織(3DST)により再生された軟骨の摩擦特性(S09-3 関節のバイオメカニズム(3),S09 関節のバイオメカニズム)

概要

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Synovial cells obtained from the synovial membrane of porcine knee joints were cultured in DMEM in monolayer. Seven days after the injection of ascorbic acid 2-phosphate, the synthesized matrices were allowed active contraction for 8 hours to develop 3-D synthetic tissues (3DSTs). A round-shaped cartilage defect of 8mm in diameter and 1.5mm in depth was created on the medial condyle of the femur. The defect was filled with the 3DST, and the porcine were allowed cage activity. Six months after the surgery, a cylindrically shaped cartilage-subchondral bone specimen of 4mm in diameter and 4mm in depth was extracted and subjected to a reciprocal frictional test. Results revealed that, the coefficient of friction of cartilage regenerated with 3DST against the glass plate was same level as that of normal cartilage.
社団法人日本機械学会の論文
2006-09-15