1121 X線マイクロCTによるラット脛骨の構造解析 : 運動負荷停止および下肢固定解除の影響(OS-5 リモデリング・マイクロバイオメカニクス)

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Nine-weeks-old Wistar rats were subjected to either treadmill running (Run group, 1.6 km/h, 1 h/day, 6 days/wk) or right hindlimb immobilization (Imm group) for 15 wks. Then, their activities were changed from Run or Imm to normal activities (Run/Sed or Imm/Rem group, respectively). Non-treated, age-matched rats were used as Control group. Tibiae were harvested from these rats at 0, 3, 7, 15, 16, 18, 22, and 30 wks. A micro X-ray CT system was employed to perform morphological analyses of transverse cross sections of the proximal metaphysis of each tibia. Cortical bone area was not changed by running nor by the restoration of normal activities. However, it was significantly decreased by immobilization, and the reduced area was maintained until 30 wks, when it returned to Control level. Trabecular thickness was not changed by running ; however, it increased after the termination of running and became significantly larger than that in Control group at 22 wks. By contrast, trabecular thickness was decreased by immobilization, which remained unchanged throughout remobilization period with a significant deference at 30 wks. The aspect ratio of the fabric ellipse obtained from trabecular bone structure was significantly larger in Run group than in Control group at 15 wks. The aspect ratio did not change much in Run/Sed group and significantly larger than that in Control group at 30 wks. These results indicate that the structure of cortical and cancellous bones in the tibial proximal metaphysis differently change in response to exercise and immobilization, and subsequent activity changes.
一般社団法人日本機械学会の論文
2000-03-16

1121 X線マイクロCTによるラット脛骨の構造解析 : 運動負荷停止および下肢固定解除の影響(OS-5 リモデリング・マイクロバイオメカニクス)

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