10505 特定たんぱく質欠落マウスの膝蓋腱強度 : 生体線維の力学特性におよぼすバイグリカンの影響(Visual Presentation Contest)

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Intact patellar tendons (PTs) and healing PTs of normal mice and biglycan-knockout mice (B.KO. mice) that hereditarily lacked in a leucinerich proteoglycan (protein), named biglycan, were used in the present study. For the determination of the effect of biglycan on the mechanical properties of biological fibrous tissues. The midsubstance of the PTs of the mice (12 wks old) were surgically removed, and they were allowed for a cage activity for subsequent 4 weeks. The tensile test was performed for the patella-1/3 healing tendon-tibia complex at a rate of 0.01mm/s using a micro tensile tester developed in our laboratory. Results revealed that, in intact PTs, the lack of biglycan increased the tangent modulus, while leaving the maximum stress to a normal value. In healing PTs, the lack of biglycan decreased both the maximum stress and strain of failure, while leaving the modulus to a normal value. Note that the rupture site varied very much among the B.KO. mice. These results indicate that (1) the lack of biglycan increases the modulus of the intact PT, (2) reduces the strength and strain at failure of the healing PT, and (3) affects the mechanical property of the bone insertion site of the tendon fiber.
社団法人日本機械学会の論文
2005-03-17