超高分子量ポリエチレンのトライボロジ特性と磨耗粉の細胞毒性(OS.2 バイオエンジニアリング)

概要

論文の詳細を見る
The ultra high molecular polyethylene (UHMWPE) with the molecular weight of 115x10^4, 249x10^4, and 340x10^4 were manufactured. The additive, density, and molecular weight distribution of the specimens were controlled to be identical to each other. A friction test using a reciprocating tester revealed that the coefficient of friction of the specimen excluding anti-oxidant monotonically increased with friction distance. The contact of UHMWPE wear particles with macrophages for 48 hours was performed by means of a newly developed cell culture method; flip cell culture method. Lactate dehydrogenase (LDH) activity was measured to evaluate the cell toxicity of the wear particle. Molecular weight dependence was observed in the cell toxicity; the LDH activity was highest in the specimen with molecular weight of 240x10^4. The number of wear particle smaller than 15 μm was also largest in the specimen. These results suggest that the molecular weight of UHMWPE affects the size of wear particle, and the size then affects the cell toxicity.
社団法人日本機械学会の論文
2004-03-03