Characterization of Transthyretin in the Pacific Bluefin Tuna, Thunnus orientalis(Physiology)

概要

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A cDNA encoding transthyretin was cloned from the Pacific bluefin tuna (Thunnus orientalis). This cDNA contains a complete open reading frame encoding 151 amino acid residues. The deduced amino acid sequence is 81% and 55% identical to the gilthead seabream and common carp forms, respectively, and 33-39% to mammalian, reptilian, and amphibian forms. A 1.0-kb transcript was found in the the liver and ovary; the liver is the main source of this protein. Analysis of triiodo-L-thyronine (T_3) and L-thyroxine (T_4) binding demonstrated that both T_3 and T_4 bind to bluefin transthyretin. The binding activity of T_3 for bluefin transthyretin is higher than that of T_4. These results indicate that bluefin transthyretin acts as a transporter of thyroid hormones (THs) in the plasma, and plays an important role in the function of THs in target cells.
社団法人日本動物学会の論文
2006-05-25