Dependence of Lipid-Lipoprotein Metabolism on Exercise Intensity in Experimental Fatty Liver Rats

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概要

• 論文の詳細を見る

• To develop experimental fatty liver, Wistar male rats were fed a high fat, high cholesterol (Cho) diet for 6 weeks after which their diet was changed to standard chow. The animals were then divided by random selection into a sedentary group (SG) and four treadmill exercise groups for 6 weeks as follows: walking group (WG, 10m/min, 60 min); low-speed running group (LRG, 20m/min, 30 min); middle-speed running group (MRG, 30m/min, 20 min) and high-speed running group (HRG, 40m/min, 15 min). The serum concentration of very low density lipoprotein (VLDL) and low density lipoprotein (LDL)-Cho decreased, and high density lipoprotein (HDL)-Cho increased in WG compared with the other three exercise groups. Hepatic triglyceride (TG) was significantly lower (P<0.05) in WG than in SG. Hepatic Cho was lower in HRG than in the other three exercise groups, and Cho in the aortic wall was higher. The results suggest that light exercise, such as walking might be more beneficial to lipid-lipoprotein metabolism than strong exercise, such as high-speed running. This is consistent with suggestion that light exercise might be effective in clinical treatment for hyperlipidemia, arteriosclerosis or fatty liver.

• 東海大学の論文

著者

• NAKANO Shoichi

  Department of Physiology III, Shcool of Medicine, Tokai University

• Nakano Shoichi

  Department Of Physiology Tokai University School Of Medicine

• TERAO Tamotsu

  Department of Physiology, School of Medicine, Tokai University

• YAMASHITA YASUHIRO

  Department of Pediatrics and Child Health, Kurume University School of Medicine

• Terao Tamotsu

  Department Of Physiology Tokai University School Of Medicine

• Yamashita Yasuhiro

  Department Of Physiology 3 School Of Medicine Tokai University

• FUJISE Takehiko

  Department of Physiology 3, School of Medicine, Tokai University

• Yamashita Yasuhiro

  Department Of Chemistry School Of Science The University Of Tokyo

• Fujise T

  Tokai Univ. School Of Medicine

• Nakano Shoichi

  Department Of Physiology Iii Shcool Of Medicine Tokai University

• Yamashita Yasuhiro

  Department of Biotechnology, Faculty of Engineering, Kansai University

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