Effect of the Adrenergic β_3-agonist, BRL37344, on Heat Production by Brown Adipocytes in Obese and in Older Rats
スポンサーリンク
概要
- 論文の詳細を見る
Heat production by isolated brown adipocytes, from hypothalamic obese rats and from older rats, was investigated by microcalorimetry. The obese and older rats were 12 and 40 weeks-old, respectively. The basal heat production by the brown adipocytes was significantly less in the obese and older rats than in control rats 12 weeks of age. Isoproterenol and a novel adrenergic β_3-agonist, BRL37344, increased heat production in a concentration-dependent manner in all rats. The effects of isoproterenol were significantly less in the obese group than in the controls, while BRL37344 stimulated heat production in all rats almost identically. These results suggest that (1) the heat producing capacity of brown adipocytes is reduced by hypothalamic obesity and aging, and (2) BRL37344 might be useful as an anti-obesity drug.
- 東海大学の論文
著者
-
TANAKA Etsuro
Department of Nutritional Science, Faculty of Applied Bio-science, Tokyo University of Agriculture
-
Tanaka E
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
-
Tanaka Etsuro
東海大学 生理
-
NAKANO Shoichi
Department of Physiology III, Shcool of Medicine, Tokai University
-
Tanaka Etsuro
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
-
Nakano Shoichi
New Materials Research Center Sanyo Electric Co. Ltd.
-
Nakano S
Functional Materials Research Center Sanyo Electric Co. Ltd.
-
Nakano Shoichi
Department Of Physiology Tokai University School Of Medicine
-
Nakano S
東海大学医学部生理科学教室
-
Nakano Shoichi
Sanyo Electric Co. Ltd.
-
YAMAKAWA Akihiko
Department of Physiology Tokai University School of Medicine
-
Nakano Shoichi
Department Of Physiology Iii Shcool Of Medicine Tokai University
関連論文
- X-ray Spectra from Weakly Ionized Linear Copper Plasma
- Low-Hydrogen-Content, Stable Amorphous Silicon Thin Films Prepared by Ion-Assisted Method
- Film Property Control of Hydrogenated Amorphous Silicon Germanium for Solar Cells
- X-ray Spectra from a Brass-target Plasma Triode
- Enhanced K-edge Angiography Utilizing Tantalum Plasma X-ray Generator in Conjunction with Gadolinium-Based Contrast Media
- Variations in Cerium X-ray Spectra and Enhanced K-Edge Angiography
- OJ-264 Novel Gene Transduction Method with Biodegradable Gelatin Hydrogel into Endothelial Progenitor Cells for Vascular Regeneration(Angiogenesis 2 (M) : OJ31)(Oral Presentation (Japanese))
- PE-328 Heavy Ion Radiation Upregulates Connexin43 and Ameliorates the Substrates for VT/VF in Rabbit Hearts after Myocardial Infarction(Arrhythmia, basic-4 (A) PE55,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- Electrical Inhomogeneity and Instability of Rabbit Ventricles after Non-Transmural Myocardial Infarction : A High-Resolution Optical Mapping Analysis(Arrhythmia, Basic 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Heavy Ion Radiation Ameliorates the Substrates for VT/VF in Rabbit Hearts after Myocardial Infarction(Arrhythmia, Basic 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Inhomogeneous Vasodilatory Responses of Rat Tail Arteries to Heat Stress : Evaluation by Synchrotron Radiation Microangiography
- Effects of Long-Term Injection of Steroid Hormone on Soluble Protein in Rat Muscles and Organellae
- Mitochondrial Space in Rat Skeletal Muscles with Long-Term Injection of Steroid Hormone
- Measurement of Cerium X-ray Spectra Using a Cerium Oxide Powder Filter and Enhanced K-edge Angiography
- X-ray Spectra from a Characteristic X-ray Generator with a Molybdenum Tube
- Quasi-Monochromatic X-Ray Generator Utilizing Graphite Cathode Diode with Transmission-Type Molybdenum Target
- Quasi-Monochromatic Flash X-Ray Generator Utilizing Disk-Cathode Molybdenum Tube
- Monochromatic polycapillary imaging utilizing a computed radiography system
- Intense Characteristic X-ray Irradiation from Weakly Ionized Linear Plasma and Applications
- Irradiation of intense characteristic x-rays from weakly ionized linear molybdenum plasma
- Endostatin inhibits tumor neovascularization via downregulation of bone marrow derived endothelial progenitor cell kinetics
- Incorporation of ex vivo expanded VEGF-expressing EPCs into foci of ischemic neovascularization
- Quasi-monochromatic x-ray irradiation from weakly ionized linear nickel plasma
- Angular dependence of x-ray spectra from a demountable x-ray tube with a copper target
- Development of an extremely soft x-ray generator
- Beneficial Role of Hydroxyfasudil, a Specific Rho-kinase Inhibitor, on Ischemia-Reperfusion Injury in Canine Coronary Microvessels in Vivo(Endothelial Function (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Myofibrils and Transverse Tubules in Glycerol-Treated Frog Skeletal Muscle
- Cerium X-ray Spectra without Filtering and their Application to High-contrast Angiography
- K-edge digital angiography using a flat panel detector with a pixel size of 50μm
- Bremsstrahlung X-ray Spectra for Enhanced K-edge Angiography
- Adrenomedullin Gene Transfer Induces Therapeutic Angiogenesis in a Rabbit Model of Chronic Hindlimb Ischemia
- Effect of Magnetic Field on the Contractility and Glycogen Content in Neuromuscular Preparation
- Phagocytes Transfected with Biodegradable Gelatin Allow Tissue-Targeted and Less Invasive Gene Therapy
- IS151 SYNCHROTORON RADIATION MICROANGIOGRAPHY CONTRIBUTES TO PATHOPHYSIOLOGY, DIAGNOSIS, AND TREATMENT OF CARDIOVASCULAR DISEASES AFTER THE YEAR 2000
- IS012 IMPROVEMENT OF MYOCARDIAL BLOOD FLOW AND METABOLISM BY GENE TRANSFER OF VEGF IN RABBIT MODEL OF CHRONIC MICROVASCULAR MYOCARDIAL ISCHEMIA
- Improvement of n-Type Poly-Si Film Properties by Solid Phase Crystallization Method
- Lateral Grain Growth of Poly-Si Films with a Specific Orientation by an Excimer Laser Annualing Method
- Development of New a-Si/c-Si Heterojunction Solar Cells: ACJ-HIT (Artificially Constructed Junction-Heterojunction with Intrinsic Thin-Layer)
- Effects of Substrate Surface Condition on a-Si Photovoltaic Characteristics : III-4: AMORPHOUS SOLAR CELLS (3) : Device Physics
- Microwave Dielectric Properties of CaO-Li_2O-Ln_2O_3-TiO_2 Ceramics
- Dielectric Characteristics of (A^_・A^_)TiO_3 Ceramics at Microwave Frequencies : Dielectric Properties
- Preparation and Characteristics of a Superconducting Base Transistor with an Au/Ba_K_xBiO_3/Niobium-Doped SrTiO_3 Structure
- Quantum Mechanical Transmission and Reflection of Quasi-Particles at Arbitrary Potential Barriers in the Superconducting Base Transistor
- Heavy ion radiation up-regulates Cx43 and ameliorates arrhythmogenic substrates in hearts after myocardial infarction
- PE-012 Arrhythmogenic Substrates in the Epicardial Borderzone of Rabbit Hearts after Myocardial Infarction : A High-Resolution Optical Mapping Analysis(Arrhythmia, Basic 3 (A) : PE2)(Poster Session (English))
- Treatment of Natto, a Fermented Soybean Preparation, to Prevent Excessive Plasma Vitamin K Concentrations in Patients Taking Warfarin
- 8 The evaluation of micro-coronary vessels using a plasma X-ray angiographic system for better management and cost/effectiveness to ischemic heart disease(Plenary Session 6 (PL6) (I) : Role of Diagnostic Imaging in the Management of Coronary Artery Diseas
- Quasi-monochromatic parallel radiography achieved with a plane-focus x-ray tube
- Regulation of Heat Production of Brown Adipocytes via Typical and Atypical β-Adrenoceptors in the Rat
- Effect of the Adrenergic β_3-agonist, BRL37344, on Heat Production by Brown Adipocytes in Obese and in Older Rats
- Trapping and Recormbination of Photogenerated Carriers in As-Growrn High-Temperature-Annealed and Light-Soaked a-Si:H
- Dependence of Open Circuit Voltage of Amorphous Silicon Solar Cells on Thickness and Doping Level of the p-Layer
- EFFECT OF DIETARY HEME-IRON INTAKES ON THE PREVENTION OF IRON-DEFICIENCY ANEMIA(Proceedings of The 8^ Asian Federation of Sports Medicine Congress 2005 Tokyo)
- A Newly Modified Isolation Method of Single Muscle Fibers : Especially Useful in Histological, Histochemical and Electron Microscopic Studies on Branched Fibers
- Enlargement of Poly-Si Film Grain Size by Excimer Laser Annealing and Its Application to High-Performance Poly-Si Thin Film Transistor
- Laser Patterning Method for Integrated Type a-Si Solar Cell Submodules
- Highly Accurate CO_2 Gas Sensor Using a Modulation-Type Pyroelectric Infrared Detector
- Modulation Type Pyroelectric IR Detector
- Preparation and Properties of a-SiGe:H:F Films by a Glow Discharge Decomposition
- Characteristics of AlN Thin Films Deposited by Electron Cyclotron Resonance Dual-Ion-Beam Sputtering and Their Application to GHz-Band Surface Acoustic Wave Devices
- High-Performance a-SiGe Solar Cells Using a Super Chamber Method
- Property Control for High-Quality Ba_K_xBiO_3 Epitaxial Thin Films Prepared by High-Pressure Reactive rf-Magnetron Sputtering
- Heterodyne Detection of Microwaves Using Granular-Type Y_1Ba_2Cu_3O_ Superconductors
- YBCO-BiO Composite Superconductor for Granular-Type Josephson Microwave Detector
- Fabrication and Properties of MgO/Bi_2Sr_2CaCu_2O_x Interfaces Using Crystalline and Amorphous MgO Films Grown by the MBE Method
- Preparation and Characterization of Nb/MgO/Bi_2Sr_2CaCu_2O_x Junctions Using the Cleavage Planes of a Single-Crystal Superconductor
- Transient Light-Induced ESR Investigations of the Role of Hydrogen in the Stability of a-Si:H
- High-Quality p-Type μc-Si Films Prepared by the Solid Phase Crystallization Method
- Improving the Uniformity of Poly-Si Films Using a New Excimer Laser Annealing Method for Giant-Microelectronics
- Stable, Metastable and Charged Dangling Bonds in Transient Light-Induced ESR of Undoped a-Si:H
- Irradiation-Temperature Dependence of the Light-Induced Effect in a-Si Solar Cells
- A Laser Welding and Scribing (LWS) Method for a High-Yield Integrated-Type a-Si Solar Cell
- Preparation of a-Si and a-Si-Alloy Films Using an Ion-Gun Chemical Vapor Deposition Method
- Interference-Free Determination of the Optical Absorption Coefficient and the Optical Gap of Amorphous Silicon Thin Films
- Amorphous Silicon-Carbon Alloy Prepared by the CMP (Controlled Plasma Magnetron) Method
- Microwave Detector Using Granular-Type YBCO Superconductors
- Preparation and Properties of a-Si Films Deposited at a High Deposition Rate under a Magnetic Field
- Preparation and Properties of a-SiGe:H Films Fabricated with a Super Chamber (Separated Ultra-High Vacuum Reaction Chamber)
- Preparation and Properties of High-Quality a-Si Films with a Super Chamber : Separated Ultra-High Vacuum Reaction Chamber
- Superlattice Structure a-Si Films Fabricated by the Photo-CVD Method and their Application to Solar Cells
- A New Analytical Method of Amorphous Silicon Solar Cells
- Light-Induced Effect of a-Si Films Fabricated Using the Super Chamber
- Effects of Swimming Exercise at Two Different Water Temperature on Hepatic Lipid and Lipoprotein Levels in Experimental Fatty Liver Rats
- Dependence of Lipid-Lipoprotein Metabolism on Exercise Intensity in Experimental Fatty Liver Rats
- High-Rate Deposition of a-Si:H Film with a Separated Plasma Triode Method
- Investigation of the Characteristics of a Piezoelectric Chopper for a Modulation-Type Pyroelectric Infrared Detector
- GHz-Barud Surface Acoustic Wave Devices Using Aluminum Nitride Thin Films Deposited by Electron Cyclotron Resonance Dual Ion-Beam Sputtering
- Preparation of c-Axis Oriented AlN Thin Films by Low-Temperature Reactive Sputtering
- Orientation Control of AlN Film by Electron Cyclotron Resonance Ion Beam Sputtering
- Properties of Yb-Ba-Cu-O Superconductors Prepared by a Plasma-Arc Melting and Rapid Quenching Method
- METABOLIC ADAPTATIONS TO ENDURANCE TRAINING MONITORED BY BLOOD LACTATE CONCENTRATION IN MALE RATS
- Effect of Time of Carbohydrate Ingestion on Muscle Glycogen Resynthesis after Exhaustive Exercise in Rats
- X-ray Spectra from Weakly Ionized Linear Copper Plasma
- Magnification K-Edge Angiography Utilizing 100-μm-Focus Tungsten Tube and Gadolinium-Based Contrast Media
- Enhanced Magnification Angiography Using 20-μm-Focus Tungsten Tube
- Characteristic X-ray Generator Utilizing Angle Dependence of Bremsstrahlung X-ray Distribution
- Variations in Cerium X-ray Spectra and Enhanced K-Edge Angiography
- Enhanced K-edge Angiography Utilizing Tantalum Plasma X-ray Generator in Conjunction with Gadolinium-Based Contrast Media
- Quasi-Monochromatic X-Ray Generator Utilizing Graphite Cathode Diode with Transmission-Type Molybdenum Target
- Quasi-Monochromatic Flash X-Ray Generator Utilizing Disk-Cathode Molybdenum Tube