Ethosuximide治療中にSLE様症状を呈した小発作の1例

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Systemic lupus erythematosus (SLE) induced by anticonvulsant drugs is well known. A young girl was observed who developed a "SLE-like" disease while under a treatment with ethosuximide for pure petit mal epilepsy. The reason for saying "SLE-like" is that this patient dose not show clinical manifestations of SLE but she shows only abnormal data on the examination of serum antinuclear antigen (ANA). This 11-year-old Japanease girl, who was born normally, had undergone good development until 7 years. When she was 8 years old, she began to suffer from petit mal epilepsy. She consulted with a specialist, who for two years gave her 200mg of acetazolamide, 200mg of ethosuximide and 60mg of phenobarbital per day. For the past two winters, she experienced Raynaud's phenomenon on her finger, at which time, the ANA was markedly positive (×320). After cessation of anticonvulsat therapy, exsudative erythema and Raynaud's phenomenon disappeared, and the ANA was reduced by ×160. After readministration of 200mg of ethosuximide and 10mg of diazepam per day, clinical seizure disappeared but ANA level elevated again. She is now free from seizure with 300mg of trimethadione and 600mg of valproic acid without any serum abnormality and any clinical manifestation of SLE. After the readministration of ethosuximide, pure petit mal eplepsy disappeared but there were a marked increase of ANA, exsudative erythema, Raynaud's phenomenon and easy fatigability. With the cessation of ethosuximide, the ANA was decreased. Therefore, the close relationship between the increase of ANA and the administration of ethosuximide was ascertained.
北里大学の論文
1980-06-30

Ethosuximide治療中にSLE様症状を呈した小発作の1例

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