成人発症の亜急性硬化性全脳炎の終夜睡眠ポリグラフ

概要

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Subacute sclerosing panencephalitis (SSPE) is known to appear in childhood, particularly in the school age child, but rarely in adulthood. We had an adult case and performed a polysomnographic study. Case: A 24 year old female. First a disturbance of memory was noticed and then mental dullness at age 22. Six months later she often fell down so she visited a medical practitioner and the condition was diagnosed as epilepsy. Consequently some kind of antiepileptics were prescribed. She fell down less frequently, but myoclonus began to appear. Subsequently she was admitted our hospital. Myoclonus and muscle rigidity were found and criteria on the serum and cerebrospinal fluid resembled that found in measles. Periodic synchronous discharge (PSD) of slow high voltage was disclosed by EEG in addition to a seizure pattern coincident with falling down. A polysomnographic study was carried out in the second stage of SSPE. The findings of polysomnography. 1) Sleep-awake cycle was still retained in this case. 2) Spindlelike waves always appeared after the PSD during light sleep. 3) The PSD interval became irregular during light sleep, but in REM sleep, the interval became regular as in waking hours.
北里大学の論文
1988-10-31