Lethal Sectoring, Genomic Instability, and Delayed Division Delay in HeLa S3 Cells Surviving Alpha- or X-irradiation
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概要
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Lethal sectoring (LS) is the process for survival in which lethal damage remaining in irradiated cells is eliminated as lethal sector (offspring without reproductive integrity). This process occurs through the postirradiation 1st to 4th divisions with the accompanying appearance of a clonogenic progenitor (clonogen)(clonogenic sectoring : CS). The features of LS or CS and genomic instability (GI) were explored by analyzing the pedigrees of HeLa cells surviving α-(0.45 Gy) or X-irradiation (3 Gy)(20% survival dose). Most (〜70%) of the lethal latent damage was eliminated from α-particle survivors through the 1st to 2nd divisions, but it persisted in X-ray survivors until the 2nd generation. Although the frequency of CS was similar to that of LS for α-irradiation, CS was higher than LS for X-irradiation. Nonlethal damage remaining in the clonogens led to an elevated incidence of delayed cell death in their progeny. The mean incidence was higher for α-particle (16.3%) than X-ray survivors (8.3%), indicating the greater potentiality for GI by α-particles. Evidence is available to suggest the intrinsic difference in the mechanisms of GI induction by these two radiations : the association of misrepaired clustered DNA damage (CD) with α-particles and unrepaired PLD with X-rays. A novel phenomenon, "delayed division delay (DDD)" was noticed, though occasionally (〜10% per cell), with the progeny during the postirradiation 1st-3rd generations. DDD was much longer in α-(mean : 〜11h) than X-irradiated cells (〜4h). Supposedly DDD was triggered by delayed chromosome breakage. However, a significant shortening of cell-cycle time at the postirradiation 1st generation was recognized with X-ray survivors.
- 日本放射線影響学会の論文
著者
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Sasaki Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Sasaki Hiroshi
Department Of Experimental Radiology Faculty Of Medicine Kyushu University:(present Address)departme
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