The Expression of L^* Protein during the Chronic Phase of Theiler's Murine Encephalomyelitis Virus (TMEV) Infection and the Role of Zinc-Binding Motif of L Protein in Virus Persistence and Demyelination
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概要
- 論文の詳細を見る
Theiler's murine encephalomyelitis virus (TMEV) is divided into two subgroups on the basis of their different biological activities. GDVII subgroup strains produce fatal polioencephalomyelitis in mice without virus persistence or demyelination. DA or TO subgroup strains induce milder polioencephalomyelitis followed by demyelination with virus persistence in the spinal cords of weanling mice. Two non-structural viral proteins, L and L, are reported to be critical in the biological activities of TMEV. In this report, we immunohistochemically demonstrate the expression of L during the chronic phase of infection by the aid of FLAG epitope. In addition, a study using a panel of mutant viruses also demonstrates that the zinc-binding motif in L-coding region is important in the escape of virus from the response of interferon during the early phase of infection.
- 金沢医科大学の論文
著者
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Sasaki Hiroshi
Department of Biological Technology, Faculty of Science and Engineering,Senshu University of Ishinom
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Takahashi Nobuo
Department Of Applied Biochemistry Hiroshima University
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Takahashi Nobuo
Department Of Ophthalmology
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Ohara Yoshiro
Department Of Mathematics Faculty Of Science Nagoya University
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Asakura Kunihiko
Department Of Microbiology Kanazawa Medical University
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Hagihara Kenta
Department of Ophthalmology
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Sasaki Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Sasaki Hiroshi
Department Of Ophthalmology
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Hagihara Kenta
Department Of Chemical Engineering And Materials Science Doshisha University
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