A Non-Structural Viral Protein, L, Is Critical in the Biological Activities of Theiler's Murine Encephalomyelitis Virus (TMEV)
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概要
- 論文の詳細を見る
Theiler's murine encephalomyelitis virus (TMEV) is divided into two subgroups on the basis of their different biological activities. GDVII subgroup strains produce fatal poliomyelitis in mice without virus persistence or demyelination. In contrast, DA or TO subgroup strains induce demyelinating disease with virus persistence in the spinal cords of weanling mice. One of non-structural proteins, leader (L), is processed from the most N-terminus of the polyprotein, and its function is still unknown. Although the homology of capsid proteins between DA and GDVII strains is over 94% at the amino acid level, that of L shows only 85%. Therefore, L is thought to be a key protein for the subgroup-specific biological activities of TMEV. Various studies demonstrated that L plays important roles in the escape of virus from host immune defenses in the early stage of infection. Further analysis of L may help elucidate the pathomechanism (s) of TMEV-induced demyelinating disease.
- 金沢医科大学の論文
著者
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Takano-maruyama Masumi
Department Of Microbiology Kanazawa Medical University
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OHARA Yoshiro
Department of Microbiology, Kanazawa Medical University
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Asakura Kunihiko
Department of Microbiology, Kanazawa Medical University
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Ohara Yoshiro
Department Of Mathematics Faculty Of Science Nagoya University
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Asakura Kunihiko
Department Of Microbiology Kanazawa Medical University
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