MUSCLE STRENGTH AND FATIGUE IN GLUCOCORTICOID-TREATED RATS
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概要
- 論文の詳細を見る
Glucocorticoids, which are prescribed as anti-inflammatory agents, can cause secondary osteoporosis and skeletal muscle atrophy. We examined the effects of glucocorticoids on the muscle strength and muscle fatigability in rats. Six-month-old female Wistar rats were randomized into two groups : 1) the control group, which received daily injections of normal saline and 2) the predonisolone (PSL) group, which received PSL 10 mg/kg daily. After a 4-week treatment period, the maximum contractile strength (to measure muscle strength) and strength decrement index (SDI) (to measure muscle fatigue) were evaluated by contractile properties using three different stimulations : 1) 20-Hz tetanic, 2) 40-Hz tetanic, and 3) 100-Hz cyclical. The cross sectional area (CSA) was measured at the left tibialis anterior (TA) muscle. Contractile muscle strength by 40-Hz tetanic stimulation, but not the other stimulations, significantly decreased in the PSL groups compared to the control group; decreases occurred in a time-dependent manner (p<0.05). The SDI in the 40-Hz stimulation was significantly increased in the PSL group compared to the control group (p<0.05). The CSA of the TA muscle in the PSL group was significantly smaller than in the control group (p<0.05). These results suggest that glucocorticoids cause a decrease in the muscle strength, a smaller fiber CSA, and an increase in muscle fatigability in the calf muscle of rats. A 40-Hz tetanic stimulation is the appropriate condition to observe contractile muscle strength or fatigue in glucocorticoid-treated rats.
- 秋田大学の論文
著者
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Sasaki Hiroshi
Department of Biological Technology, Faculty of Science and Engineering,Senshu University of Ishinom
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MIYAKOSHI Naohisa
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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KASUKAWA Yuji
Department of Neurosurgery, National Defense Medical College
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SHIMADA Yoichi
Department of Neurosurgery, National Defense Medical College
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Shimada Yoichi
Department Of Neurosurgery National Defense Medical College
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Shimada Yoichi
秋田大学 整形外科学
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Kasukawa Yuji
Department Of Neurosurgery National Defense Medical College
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Shimada Yoichi
Department Of Anesthesiology Nippon Medical School
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Yoichi Shimada
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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Hiroshi Sasaki
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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Naohisa Miyakoshi
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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Yuji Kasukawa
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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Shigeto Maekawa
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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Hideaki Noguchi
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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Keiji Kamo
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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Kamo Keiji
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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NOGUCHI Hideaki
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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MAEKAWA Shigeto
Department of Orthopedic Surgery, Akita University Graduate School of Medicine
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Yuji Kasukawa
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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Maekawa Shigeto
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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Noguchi Hideaki
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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Miyakoshi Naohisa
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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Miyakoshi Naohisa
Division Of Orthopedic Surgery Department Of Neuro And Locomotor Science Akita University School Of
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Naohisa Miyakoshi
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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Miyakoshi Naohisa
Department Of Orthopedic Surgery Akita University
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Shimada Yoichi
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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Sasaki Hiroshi
Department Of Orthopedic Surgery Akita University Graduate School Of Medicine
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Shimada Yoichi
Biomedical Imaging Laboratory Graduate School Of Biomedical Engineering Tohoku University
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Sasaki Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Hatakeyama Yuji
Department Of Orthopedic Surgery Nakadori General Hospital
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