Effect of methotrexate on local cerebral blood flow in conscious rats.
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概要
- 論文の詳細を見る
The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [<SUP>14</SUP>C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.
- 公益社団法人 日本薬理学会の論文
著者
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Uemura Kazuo
Department Of Pharmacology Hamamatsu University School Of Medicine
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KONDOH Yasushi
Department of Neurology, Akita Research Institute of Brain and Blood Vessels
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Mizusawa Shigenori
Department Of Internal Medicine Akita Research Institute Of Brain And Blood Vessels
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Komatsu Kazuo
Department Of Information And Computer Sciences Kumamoto National College Of Technology
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Ono Yukihiko
Department Of Cardiology Research Institute For Brain And Blood Vessels-akita
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Takahashi Akira
Department Of Advanced Materials Science And Engineering Faculty Of Engineering Yamaguchi University
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Watanabe Katsuhiro
Department Of Biological Science Faculty Of Agriculture Yamaguchi University
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Sasaki Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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ONO Yukihiko
Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita
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KONDOH Yasushi
Department of Neurology, Research Institute for Brain and Blood Vessels-Akita
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NAKAMICHI Hiroyuki
Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita
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MURAKAMI Matsutaro
Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita
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KUDOH Yasutsugu
Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita
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TAKAHASHI Akira
Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita
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MIZUSAWA Shigenori
Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita
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