Indoloquinoxaline誘導体の金属錯体に関する研究(第3報) : 1-および4-Hydroxyindoloquinoxalineの金属錯体

概要

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Acid dissociation constants (pK_a) of 1-hydroxyindoloquinoxaline (I) and 4-hydroxy- indoloquinoxaline (II), and stability constants (log β_2) of their complexes with copper, nickel, cobalt, zinc, and cadmium were determined by potentiometric measurements according to the Bjerrum method. Acid dissociation constants of I and II were 10.4 and 10.55,respectively. The stability constants of the metal complexes of I and II were found to be in good agreement with the order of Mellor-Maley series, except 1-hydroxyindoloquinoxaline-nickel complex. Thermogravimetric and infrared spectral analyses, as well as elemental analyses, were made on the metal complexes synthesized. Elemental analysis of nickel complex of I indicated that the complex possessed two molecules of water, which may be assumed to be coordinated water by thermogravimetric analysis. Therefore, nickel complex of I may be considered to take hexacoordinated aquo-type structure, while nickel complex of II may have tetracoordinated structure.
公益社団法人日本薬学会の論文
1970-05-25