Monoester Formation by Hydrolysis of Dialkyl Phthalate Migrating from Polyvinyl Chloride Products in Human Saliva
スポンサーリンク
概要
- 論文の詳細を見る
The migration dialkyl phthalate was tested in volunteers who chewed polyvinyl chloride(PVC)toy products under controlled conditions. The PVC toy samples consisted of ball A containing 100 and 185 mg/g di-n-butyl phthalate(DBP)and di-2-ethylhexyl phthalate(DEHP)respectively, and ball B, containing 256 mg/g diisononyl phthalate(DINP). The migration of diatkyl phthalate into simulated saliva was also tested in vitro by shaking toy samples. The migration rates of DBP, DEHP and DINP from balls A and B were 11.7, 44.4 and 78.0 μg/10 cm^2/hr, respectively, in vivo, and 339, 315 and 535 μg/10 cm^2/hr, respectively, in vitro. The presence of mono-n-butyl phthalate(MBP)and mono-2-ethylhexyl phthalate(MEHP)in saliva collected after chewing ball A was confirmed by GCMSSIM. Human saliva which collected from volunteers incubated with DBP and DEHP at 37℃ over 60 min, hydrolyzed these compounds to their monoesters.
- 公益社団法人日本薬学会の論文
- 2001-06-01
著者
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ISHIWATA Hajimu
National Institute of Health Sciences
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Onodera Sukeo
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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NIINO Tatsuhiro
Tokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences
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ISHIBASHI Tohru
Tokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences
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SAKAI Senzo
Tokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences
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YAMADA Takashi
Japan Food Additives Association
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Sakai Shinobu
Hokkaido Institute Of Environmental Science
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Sakai Senzo
Tokyo Kenbikyo-in Foundation Center Of Food & Environmental Sciences
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Onodera S
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Onodera Sukeo
Faculty Of Pharmaceutical Science Science University Of Tokyo
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Onodera Sukeo
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Niino Tatsuhiro
Mitsubishi Chemical Safety Institute Ltd.
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Itho Takeshi
Tokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences
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Ishiwata Hazimu
National lnstitute of Health Sciences
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Itho Takeshi
Tokyo Kenbikyo-in Foundation Center Of Food & Environmental Sciences
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Ishibashi Tohru
Tokyo Kenbikyo-in Foundation Center Of Food & Environmental Sciences
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Niino Tatsuhiro
Tokyo Kenbikyo-in Foundation Center Of Food & Environmental Sciences
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Yamada Takashi
National Institute Of Health Sciences
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Ishibashi Tohru
Tokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences
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