Some Properties of Nitrosation-Accelerating Substance (s) in Sodium Chondroitin Sulfate Preparations
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概要
- 論文の詳細を見る
Contaminant (s) in sodium chondroitin sulfate (SCS) preparations can strongly accelerate formation of nitrosamines from secondary amines and nitrite. About 70% of nitrosation-accelerating activity (NAA) was recovered in the filtrate through a DIAFLO YC 05 ultrafiltration membrane. The results of ultrafiltration and column chromatography using Sephadex G-10 identified that the molecular weight of the main component that showed NAA was several hundreds. It reacted with nitrite and gradually lost its NAA. It did not accelerate formation of nitrosomethylurea. It accelerated formation of nitrosodimethylamine additively with thiocyanate, a well known accelerator of nitrosamine formation.
- 公益社団法人日本薬学会の論文
- 1988-12-31
著者
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YAMADA Takashi
National Institute of Health Sciences (NIHS)
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Yamamoto Miyako
National Institute Of Hygienic Sciences
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Yamada T
National Inst. Health Sci. Tokyo Jpn
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Yamada Takashi
National Institute Of Health Sciences
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