Studies on the Method of Size Reduction of Medicinal Compounds. IV. Solvate Formation of Chloramphenicol and Its Application to Size Reduction

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概要

• 論文の詳細を見る

• Crystals of chloramphenicol obtained from about 30 kinds of solvents were analyzed by differential scanning calorimetry (DSC) for the detection of solvate formation. It was found that heterocyclic solvents such as pyridine and picolines formed solvates with chloramphenicol. Thermal behaviours of these solvates were further investigated by DSC under various conditions, by gas evolution analysis and by thermogravimetric analysis. The one-to-one solvate with pyridine was found most suitable to the size reduction by solvation and desolvation. The specific surface area of the desolvated chloramphenicol was 3.0-3.1 m^2/g. The heat of desolvation and the heat of transformation from the pyridinate to the desolvated chloramphenicol were 6.3±0.5 kcal/mole and 5.0±0.5 kcal/mole, respectively. Also, the activation energy for the desolvation reaction was estimated by both the methods of Ozawa and Kissinger to be 20.6±1.6 kcal/mole and 20.0±0.8 kcal/mole, respectively.

• 社団法人日本薬学会の論文
• 1971-05-25

著者

• 菅家 甫子

  School Of Pharmaceutical Sciences Kitasato University

• 関口 慶二

  School of Pharmaceutical Sciences, Kitasato University

• 堀越 勇

  Faculty of Pharmaceutical Sciences, Toyama University

• 堀越 勇

  Faculty Of Pharmaceutical Sciences Toyama University

• 氷室 育三

  School of Pharmaceutical Sciences, Kitasato University

• 津田 洋二

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 関口 慶二

  Kitasato University School of Pharmaceutical Sciences

• 関口 慶二

  School Of Pharmaceutical Sciences Kitasato University

• 津田 洋二

  Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 氷室 育三

  School Of Pharmaceutical Sciences Kitasato University

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