固形薬剤中の水分に関する研究(第6報) : 着色度の推定法に関する一考察
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概要
- 論文の詳細を見る
Coloration of solid pharmaceutics was assumed to proceed through the formation of a kind of solution system by the water of hydration contained in the pharmaceutics and examinations were made to see if reaction kinetics in dilute solution could be applied in this case. It was thereby found that coloring rate was proportional to the rate of hydration in simple powders, and a linear relation was found to hold between coloring rate constants and the reciprocal of absolute temperature. If conditions were selected, periodical change of such coloration could be predicted as in the case of dilute solutions. On the bases of these ideas, examinations were made also on granules and tablets, and comparison of the values calculated from the result of acceleration tests and those obtained on actual samples by standing for some period at room temperature showed fairly good agreement.
- 社団法人日本薬学会の論文
- 1966-04-25
著者
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堀越 勇
Faculty of Pharmaceutical Sciences, Toyama University
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堀越 勇
Faculty Of Pharmaceutical Sciences Toyama University
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堀越 勇
中外製薬株式会社研究所
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畑 俊一
中外製薬株式会社研究所
関連論文
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- Thermal Analysis of Organic Medicinals. I. Detection of the Molecular Compound Formation by the Differential Thermal Analysis and by the Differential Scanning Calorimetry
- Studies on the Method of Size Reduction of Medicinal Compounds. III. Size Reduction of Griseofulvin by Solvation and Desolvation Method using Chloroform. (3)
- Studies on the Method of Thermal Analysis of Organic Medicinals. VI. Simultaneous Measurement of the Differential Temperature and of the Dielectric Behavior
- 固形薬剤中の水分に関する研究(第6報) : 着色度の推定法に関する一考察
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