Effect of Sorbed or Adsorbed Water in Powdery Medicaments on Tablet Compressibility

概要

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The recompression time dependencies of dynamic loss energy and of the maximum displacement of the upper punch on sorbed or hydrated and anhydrous three compounds of potato starch, dicalcium phosphate and glucose were studied. In every case of our experiments, a linear relationship was found to exist between dynamic loss energy and the maximum displacement of the upper punch. The gradient of the linear relationship expresses an amount of heat generation per unit viscous deformation (J/mm) in recompression and can be utilized as a parameter of solid medicament to evaluate its tablet compressibility. The values of those gradients were much influenced by the sorbed water in potato starch, but a little by the water of hydrated form in dicalcium phosphate and glucose.
社団法人日本薬学会の論文
1977-04-25