固形薬剤中の水分に関する研究(第4報) : グルクロン酸誘導体水和物の誘電的性質

概要

論文の詳細を見る
Water of hydration contained in glucuronamide, potassium glucuronate, and sodium glucuronate isoniazone has different nature. In order to comparatively examine their nature, specific polarization of water (P_w) was calculated from the measurement of apparent dielectric constant (ε'_a) at the time of adsorption isotherm, from the enthalpy of evaporation and standard entropy by measurement of dissociation water vapor pressure. Infrared spectra and X-ray diffraction of the hydrated and anhydrate compounds were also measured. It was thereby found that water in these hydrates dose not show correlation between the quantity of adsorption and specific surface area, such as in seen in silica gel. Consequently, water of hydration in these compounds is not an adsorbed water but a stable water of crystallization in glucuronamide, while that in the other two compounds is a water of crystallization in a limited sense although their water of hydration is labile due to reversibility of adsorption and desorption.
社団法人日本薬学会の論文
1966-04-25