固形薬剤中の水分に関する研究(第3報) : グルクロン酸誘導体の結晶水について

概要

論文の詳細を見る
In the hydrated derivatives of glucuroic acid glucuronamide monohydrate, potassium glucuronate dihydrate, and sodium glucuronate isoniazone dihydrate, water of hydration present has different properties. These hydrates were submitted to the measurement of changes in weight, dielectric constant, and differential heat, activation energy of dehydration, and specific surface area by the BET method. The result of these measurements threw doubt on whether water of hydration in one mole of potassium glucuronate dihydrate and two moles on sodium glucuronate isoniazone dihydrate could be strictly called water of crystallization in its limited sense. Even if such water of hydration could be included in the scope of the water of crystallization, such water will be a problem in the manufacture of pharmaceutical preparations.
社団法人日本薬学会の論文
1966-04-25