Studies on the Method of Size Reduction of Medicinal Compounds. III. Size Reduction of Griseofulvin by Solvation and Desolvation Method using Chloroform. (3)

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概要

• 論文の詳細を見る

• In order to find the limit of size reduction by the method of solvation and desolvation, the effect of repeated solvation and desolvation of CHCl_3 on the specific surface area of griseofulvin particles was investigated by the BET gas adsorption method. It was found that the antibiotics was effectively pulverized by a single application of the method. The applicability was also tested with several substances forming solvates and hydrates and the specific surface areas were all found to be 2-3m^2/g, unless a solution was formed during the desolvation process. The heat of solvation of griseofulving with CHCl_3 and the heat of activation of the desolvation reaction were estimated to be 6.4±0.5 and 20±1 kcal/mole by the differential scanning calorimetry and gas evolution analysis.

• 社団法人日本薬学会の論文
• 1968-12-25

著者

• 関口 慶二

  School of Pharmaceutical Sciences, Kitasato University

• 堀越 勇

  Faculty of Pharmaceutical Sciences, Toyama University

• 堀越 勇

  Faculty Of Pharmaceutical Sciences Toyama University

• 堀越 勇

  School of Pharmaceutical Sciences, Kitasato Memorial University

• 永室 育三

  School of Pharmaceutical Sciences, Kitasato Memorial University

• 関口 慶二

  Kitasato University School of Pharmaceutical Sciences

• 関口 慶二

  School Of Pharmaceutical Sciences Kitasato University

• 永室 育三

  School Of Pharmaceutical Sciences Kitasato Memorial University

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