Co-operative Effects of an Inhibitor NH^+_4 and of an Activator K^+ on the Acid Secretory Rate in Frog Gastric Mucosa in Vitro : A Multi-Enzyme System
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概要
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Effects of concentrations of ammonium ion (NH^+_4) and potassium ion (K^+) in the serosal solution on the acid secretory rate by bullfrog gastric mucosa were studied at near saturating substrates concentrations in vitro. The hydrogen chloride production system was treated as a multi-enzyme system. From kinetic analyses, the system was found to have co-operativities with regard to the activator K^+ and the inhibitor NH^+_4. The co-operativity of the inhibitor increased as the K^+ concentration increased. The co-operativity of K^+ increased as the NH^+_4 concentration increased. Considering the fact that chloride ion (Cl^-) and thiocyanate ion (SCN^-) do not have co-operativities, it was suggested that SCN^- inhibits the Cl^- transport chain reaction and that NH^+_4 inhibits the hydrogen (H^+) transport chain reaction. It was also discussed that NH^+_4 and SCN^- were not uncoupler-type inhibitors like 2,4-dinitrophenol.
- 社団法人日本薬学会の論文
- 1976-03-25
著者
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竹口 紀晃
Faculty of Pharmaceutical Sciences
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堀越 勇
Faculty of Pharmaceutical Sciences, Toyama University
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堀越 勇
Faculty Of Pharmaceutical Sciences Toyama University
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