Solvate Formation of Griseofulvin with Alkyl Halide and Alkyl Dihalides

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概要

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• Six solvates of griseofulvin with alkyl halide and alkyl dihalides were isolated, and their crystallographic as well as physico-chemical propetries were investigated by infrared spectroscopy, powder X-ray diffiractometry, x-ray crystallographic analysis, thermogravimetry (TG) and differential scanning calorimetry (DSC). From the weight loss in TG curves, the combining ratios between the drug and solvent were determined to be 1 : 1 except for that of griseofulvin 1-bromo-2-chloroethane solvate (drug : solvent=1 : 0.8). The cell dimensions of griseofulvin bromoethane solvate and griseofulvin dibromomethane solvate were almost equal, and the solvates fromed a new type of mixed crystal (substitutional solid solution).From X-ray crystallographic analysis, it was elucidated that the molecular arrangement in the dichloroethane solvate crystal was the same as that in the chloroform solvate determined by Shefter et al.

• 社団法人日本薬学会の論文
• 1988-10-25

著者

• 鈴木 悦子

  School Of Pharmaceutical Sciences Kitasato University

• 森田 豊

  Products Formulation Research Laboratory Eisai Co. Ltd.

• 関口 慶二

  School of Pharmaceutical Sciences, Kitasato University

• 城谷 憲一

  School of Pharmaceutical Sciences, Kitasato University

• 森田 豊

  School of Pharmaceutical Sciences, Kitasato University

• 城谷 憲一

  School Of Pharmaceutical Sciences Kitasato University

• 関口 慶二

  School Of Pharmaceutical Sciences Kitasato University

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