バルビツール酸誘導体とジメチルアミン間の分子付加物の形成

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概要

• 論文の詳細を見る

• Adduct formation with dimethylamine was confirmed in 5 barbiturates including allobarbital, amobarbital, barbital, cyclobarbital, and hexobarbital. The thermal and physico-chemical properties of these adducts were investigated by differential scanning calorimetry, thermogravimetry, infrared spectroscopy, and X-ray powder diffractometry. From the weight decrease in thermogravimetry, the combining ratios of adducts (barbiturates : dimethylamine) were determined to be 1 : 1 for allobarbital and hexobarbital, and 1 : 2 for amobarbital and barbital. As the new absorption band arising from NH_2^+ stretching vibration appeared in infrared spectra of all adducts except hexobarbital-dimethylamine, it was suggested that the bonding of an ionic nature would participate in the adduct formation of four barbiturates. In addition, the complicated thermal behavior of the adducts was discussed.

• 社団法人日本薬学会の論文
• 1982-12-25

著者

• 清水 澄

  Faculty Of Pharmaceutical Sciences Teikyo University

• 鈴木 悦子

  School Of Pharmaceutical Sciences Kitasato University

• 津田 泰之

  北里大薬

• 津田 泰之

  School Of Pharmaceutical Sciences Kitasato University

• 関口 慶二

  School of Pharmaceutical Sciences, Kitasato University

• 城谷 憲一

  School of Pharmaceutical Sciences, Kitasato University

• 鈴木 悦子

  北里大学薬学部

• 岡本 喜久子

  School of Pharmaceutical Sciences, Kitasato University

• 関口 慶二

  北里大学薬学部

• 津田 泰之

  北里大学薬学部

• 城谷 憲一

  北里大学薬学部

• 清水 澄

  帝京大学薬学部

• 岡本 喜久子

  北里大学薬学部

• 城谷 憲一

  School Of Pharmaceutical Sciences Kitasato University

• 関口 慶二

  School Of Pharmaceutical Sciences Kitasato University

• 岡本 喜久子

  School Of Pharmaceutical Sciences Kitasato University

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