Thermal, Physicochemical, and Micromeritic Properties of Freeze-dried Chloramphenicol Palmitate
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概要
- 論文の詳細を見る
The size reduction of chloramphenicol palmitate to a submicron level was accomplished by the freeze-drying of a solution composed of chloramphenicol palmitate and benzene. The crystal form of the resulting powder was characterized by using X-ray diffractometry, infrared spectroscopy, and differential scanning calorimetry (DSC). The first two methods showed the powder to be polymorph B, but DSC measurements indicated that it contains a trace (or seeds) of polymorph A. This was confirmed by hot-stage microscopy. The dissolution rates and solubilities of freeze-dried powders and polymorph A were determined.
- 社団法人日本薬学会の論文
- 1983-02-25
著者
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鈴木 悦子
School Of Pharmaceutical Sciences Kitasato University
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関口 慶二
School of Pharmaceutical Sciences, Kitasato University
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千原 薫
School of Pharmaceutical Sciences, Kitasato University
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千原 薫
北里大学薬学部
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関口 慶二
School Of Pharmaceutical Sciences Kitasato University
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