スルホニル尿素誘導体とアンモニア間の分子付加物形成とその微粉化への応用

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概要

• 論文の詳細を見る

• Ammonia adduct formation was confirmed in 5 sulfonylureas including acetohexamide, glyclopyramide, chlorpropamide, tolazamide, and tolbutamide. The thermal and physico-chemical properties of these adducts and the recovered chemicals were investigated by differential scanning calorimetry, thermogravimetry, thermomicroscopy, X-ray powder diffractometry, and scanning electron microscopy. From the specific surface area measurement by a gas adsorption (BET) method, it was found that effective particle size reduction was achieved with sulfonylureas recovered by desorbing NH_3 from the adducts. Further, the effect of particle size on the temperature range of melting and the heat of fusion was investigated with glyclopyramide, tolazamide, and tolbutamide. It was found that, in spite of the same purity, the melting peaks of size-reduced particles via these NH_3 adducts became sharper but shifted to lower temperature and the heats of fusion were smaller than those of the original sulfonylureas.

• 公益社団法人日本薬学会の論文
• 1981-01-25

著者

• 津田 泰之

  北里大薬

• 津田 泰之

  School Of Pharmaceutical Sciences Kitasato University

• 関口 慶二

  School of Pharmaceutical Sciences, Kitasato University

• 関口 慶二

  北里大学薬学部

• 津田 泰之

  北里大学薬学部

• 関口 慶二

  School Of Pharmaceutical Sciences Kitasato University

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