Ammonia Adducts of Chloramphenicol and Chloramphenicol Palmitate and Their Application to Particle Size Reduction
スポンサーリンク
概要
- 論文の詳細を見る
It was confirmed that chloramphenicol and chloramphenicol palmitate form NH_3 adducts with combining ratios of 1 : 2 (chloramphenicol : NH_3), and 1 : 2 and 1 : 1 (chloramphenicol palmitate : NH_3). The thermal and physico-chemical properties of their NH_3 adducts and the recovered chemicals were investigated by differential scanning calorimetry, infrared spectroscopy, X-ray diffractometry, and scanning electron microscopy. Elimination of NH_3 from the adducts of chloramphenicol and chloramphenicol palmitate proceeded readily at normal temperatures and pressure to yield very fine particles of the original chemicals. Further, the effect of repeating the process of sorption and desorption of NH_3 on particle size was investigated in the case of chloramphenicol palmitate by the gas adsorption method. Two or more repetitions of the process produced a significant increase in specific surface area.
- 公益社団法人日本薬学会の論文
- 1980-03-25
著者
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菅家 甫子
School Of Pharmaceutical Sciences Kitasato University
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津田 泰之
北里大薬
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津田 泰之
School Of Pharmaceutical Sciences Kitasato University
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関口 慶二
School of Pharmaceutical Sciences, Kitasato University
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宮地 勲
Seikagaku Kogyo, Co., Ltd.
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関口 慶二
School Of Pharmaceutical Sciences Kitasato University
-
宮地 勲
Seikagaku Kogyo Co. Ltd.
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